Hasan Erbil Abaci, PhD

Profile Headshot

Overview

Dr. Abaci received his Ph.D. degree from the Johns Hopkins University in bioengineering and his postdoctoral trainings in Cornell and Columbia Universities working on tissue engineered models of microvasculature and skin and tissue-on-a-chip platforms.

Academic Appointments

  • Assistant Professor of Dermatology

Gender

  • Male

Credentials & Experience

Education & Training

  • PhD, Bioengineering, Johns Hopkins University
  • Fellowship: Cornell University
  • Fellowship: Columbia University

Research

Our research essentially focuses on recapitulating and understanding the chemical and biomechanical microenvironment in skin morphogenesis and regeneration using advanced 3D human skin models. We are particularly interested in the development and maintenance of skin-specific vasculature and its regulation by the skin microenvironment. Our approach is based on reconstructing the integumentary system in vitro at different levels of complexity through microfluidic-based iPSC-derived organoids, and ii) 3D-printed multicomponent skin models to primarily study the skin microvasculature and its unique functions during the skin development, homeostasis and inflammation. The skin is a complex organ containing more than 50 different cell types and various components and appendages. Therefore, the ability to generate physiologically-relevant human skin tissues allows us to dissect individual roles of various microenvironmental factors, including cell-cell and cell-ECM interactions in both normal and disease states of the human skin.

Research Interests

  • Microfluidic models of human skin development and regeneration
  • Recapitulation of skin-vascular interactions in engineered platforms
  • Spatially-controlled organoids of complex epithelium
  • Understanding skin-specific vasculature in health and inflammation

Grants

GENERATING MORPHOGEN GRADIENTS TO ENGINEER HUMAN INTEGUMENTARY ORGANOIDS (Federal Gov) (PI: Abaci)
Sep 15 2020 – Sep 14 2023

DRUG SCREENING WITH A BIOFRABICATED 3-D IMMUNOCOMPETENT SKIN MODEL FOR DRUG DISCOVERY IN PSORIATIC DISEASE (Federal Gov) (Co-I: Abaci)
Sep 1 2020 – Aug 31 2023

CLINICAL TRIALS IN A DISH USING A PERSONALIZED MULTI-TISSUE PLATFORM FOR ATOPIC DERMATITIS (Federal Gov) (Co-I: Abaci)
Sep 1 2020 – Aug 31 2021

IDENTIFYING SKIN-SPECIFIC VASCULATURE AND VASCULAR BASEMENT MEMBRANE IN A BIOMIMETIC 3D SKIN MODEL (Private) (PI: Abaci)
Dec 31 2019 – Dec 30 2021

SYNTHETIC DEVELOPMENTAL TISSUE ENGINEERING OF HAIR FOLLICLES (Federal Gov) (PI: Abaci)
Sep 12 2017 - Aug 31 2022

MULTI-TISSUE PLATFORM FOR MODELING SYSTEMIC PATHOLOGIES (Federal Gov)(Co-I: Abaci)
Sep 1 2017 – Jun 30 2022

BIOPRINTING 3D SKIN FOR PATIENT-SPECIFIC DRUG DISCOVERY IN INFLAMMATORY SKIN DISEASES (Federal Gov)(Co-I: Abaci)
Sep 25 2017 – Jul 31 2019

GENERATION OF FUNCTIONAL HUMAN HAIR (Private)(PI: Abaci)
July 1 2014 – Jun 30 2019